Links Found Between Breast Ductal Fluid, Breast Cancer Development

The research found differences between the ductal fluid bacteria found in women who have experienced breast cancer, and the bacteria present in those who have not.

In the study, Reid's PhD student Camilla Urbaniak obtained breast tissues from 58 women who were undergoing lumpectomies or mastectomies for either benign (13 women) or cancerous (45 women) tumors, as well as from 23 healthy women who had undergone breast reductions or enhancements.

It was then analyzed with next-generation genomic sequencing, which has also been used for examining bacteria in NASA spacecraft assembly facilities. Reid is Professor of Surgery, and Microbiology & Immunology at Western University and Director, Canadian Centre for Human Microbiome and Probiotic Research at Lawson Health Research Institute in London, Ontario, Canada. "Double-strand breaks are the most detrimental type of DNA damage and are caused by genotoxins, reactive oxygen species, and ionising radiation", said researchers.

The fix mechanism for double-stranded breaks is highly error prone and such errors can lead to the development of cancer.

The findings showed that Lactobacillus and Streptococcus, considered to be health-promoting bacteria, were more prevalent in healthy breasts than in cancerous ones.

Both groups have anticarcinogenic properties. "Yet, all breast cancer begins in the ducts, so clearly exploration is critical to discovering what causes breast cancer and how we can eradicate the disease", Dr. Susan Love, chief visionary officer of Dr. Susan Love Research Foundation, Encino, California, said in a press release.

Other research has found overweight fathers may be putting their daughters at risk of breast cancer. "Since human milk contains beneficial bacteria, we wondered if they might be playing a role in lowering the risk of cancer".

Though the study found a correlation between specific species of bacteria and women who have gone through breast cancer treatment, the cause of the bacterial population difference is unclear. "Colleagues in Spain have shown that probiotic lactobacilli ingested by women can reach the mammary gland", said Reid. "These responses can trigger inflammation and immune responses, suggesting that this interaction might help the immune system monitor breast tissue for cancer, or that certain microbes could contribute to increased inflammation that leads to cancer development", Lee said.

Using planetary protection techniques that ensure Nasa spacecraft do not contaminate other worlds, researchers, including one of Indian-origin, have found a link between bacteria in breast ductal fluid and breast cancer. Antibiotics targeting bacteria that abet cancer might be another option for improving breast cancer management, said Reid.


Popolare

COLLEGARE